High-Resolution Genetic and Physical Mapping of Modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v)
| Autor: | Konrad Noben-Trauth, Marie E. Legare, Elizabeth C. Bryda, Hung J. Kim, Wayne N. Frankel |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Genes Recessive Locus (genetics) Deafness Biology Contig Mapping Mice Hearing Gene mapping otorhinolaryngologic diseases Genetics Animals Radiation hybrid mapping Allele Alleles Radiation Hybrid Mapping Polymorphism Genetic Contig Haplotype Physical Chromosome Mapping Chromosome Mapping Mice Mutant Strains Phenotype Haplotypes Mutation Female |
| Zdroj: | Genomics. 73:338-342 |
| ISSN: | 0888-7543 |
| DOI: | 10.1006/geno.2001.6538 |
| Popis: | Modifier-of-deafwaddler (mdfw) and waltzer (Cdh23v) are loci on mouse chromosome 10 encoding factors that are essential for the function of auditory hair cells. The BALB/cByJ-specific mdfw allele encodes a necessary and sufficient modifier that induces progressive early onset hearing loss in CBy-dfw2J heterozygotes. Recessive mutations in the waltzer locus result in circling behavior and congenital deafness. In this report we present a high-resolution integrated genetic and physical map of mdfw and Cdh23(v). Our genetic analyses localize mdfw between markers D10Mit60 and 148M13T7 within a 1.01-cM region. The Cdh23v critical interval is fully contained within the mdfw region and localizes between markers 146O23T7 and 148M13T7 within a 0.35-cM interval that is represented in an approximately 500-kb BAC contig. Our data suggest that mdfw and Cdh23v are allelic. |
| Databáze: | OpenAIRE |
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