BILIARY AND URINARY METABOLITES OF 4-C14-17α-HYDROXYPROGESTERONE IN HUMAN SUBJECTS*
| Autor: | A. Vermeulen, W. R. Slaunwhite, Averya. Saxdberg |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Pregnanetriol
medicine.medical_specialty Endocrinology Diabetes and Metabolism Urinary system Clinical Biochemistry Endogeny Urine Biochemistry chemistry.chemical_compound Endocrinology Internal medicine Humans Medicine Tetrahydrocortisone Progesterone business.industry 17-alpha-Hydroxyprogesterone Biochemistry (medical) 17α-Hydroxyprogesterone Metabolism Body Fluids chemistry Hydroxyprogesterone Steroids business medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 21:1534-1542 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-21-12-1534 |
| Popis: | The metabolism of 4-C14-17α-hydroxyprogesterone, injected intravenously into 6 endocrinologically normal women (3 with bile fistulas), was essentially like that described previously by other investigators for large quantities of 17α-hydroxyprogesterone. Differences from reported results were the presence of tetrahydrocortisone, the absence of significant amounts of androgenic 17-ketosteroids, and the predominance of Pregnane-3α, 17α-diol-20-one over pregnanetriol in the urine. The biliary metabolites, reported here for the first time, were similar to those in the urine. The endogenous daily production of 17α-hydroxyprogesterone was calculated to be approximately 2 mg. |
| Databáze: | OpenAIRE |
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