Therapeutic Efficiency of Spleen or Bone Marrow CFU in X-irradiated89Sr Marrow-ablated Mice
Autor: | C. Castaignos, E. Legrand, E. de Calignon, J.F. Duplan |
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Rok vydání: | 1979 |
Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Bone Marrow Cells Spleen Biology Colony-Forming Units Assay Mice Bone Marrow medicine Animals Irradiation X-Rays Hematopoietic Stem Cell Transplantation General Medicine Hematopoietic Stem Cells Transplantation Kinetics medicine.anatomical_structure Splenectomy Female Bone marrow Stem cell Previously treated |
Zdroj: | International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 36:595-600 |
ISSN: | 0020-7616 |
DOI: | 10.1080/09553007914551421 |
Popis: | SummaryExperiments were carried out to compare the therapeutic efficiency (TE: number of CFU required to reduce the mortality from 100 to 50 per cent) of spleen or marrow (BM) stem cells (CFU) grafted into lethally irradiated mice (807 rad) which had been previously treated with 89Sr or splenectomized. It was found that during the reconstitution of the haemopoietic organs, the spleen does not provide more than 10 per cent of the functional cells necessary for survival. Besides, the BM-derived CFU growing in 89Sr marrow-ablated mice remain twice as efficient as the spleen-derived ones. Similarly, spleen-derived CFU transplanted into splenectomized mice are half as efficient as BM-derived ones. It may therefore be assumed that haemopoietic stem cells grafted into a foreign microenvironment retain their original kinetics of growth and differentiation during 7 to 10 days after their transplantation. |
Databáze: | OpenAIRE |
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