Distribution of particulate matter and tissue remodeling in the human lung
Autor: | Daniel Hung, Susan S. Lin, Emily B. Bahne, Francis H. Y. Green, Cathy Saiki, Val Vallyathan, Charles G. Plopper, Venu Gopal, Margaret G. Ménache, Marc B. Schenker, Kent E. Pinkerton |
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Rok vydání: | 2000 |
Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis Connective tissue Autopsy Bronchi PM2.5 Toxicology Medical and Health Sciences California PM10 Fibrosis Parenchyma medicine Humans pigmentation Lung Aged particulate matter Air Pollutants lung pathology Chemistry fibrosis Public Health Environmental and Occupational Health Dust Environmental exposure Anatomy Environmental Exposure Particulates asthma respiratory system Middle Aged medicine.disease respiratory tract diseases medicine.anatomical_structure Respiratory Airway Environmental Sciences Research Article |
Zdroj: | Environmental Health Perspectives Environmental health perspectives, vol 108, iss 11 |
ISSN: | 0091-6765 |
Popis: | We examined the relationship between intrapulmonary particle distribution of carbonaceous and mineral dusts and remodeling of the airways along anatomically distinct airway paths in the lungs of Hispanic males from the central valley of California. Lung autopsy specimens from the Fresno County Coroner's Office were prepared by intratracheal instillation of 2% glutaraldehyde at 30 cm H(2)O pressure. Two distinct airway paths into the apico-posterior and apico-anterior portions of the left upper lung lobe were followed. Tissue samples for histologic analysis were generally taken from the intrapulmonary second, fourth, sixth, and ninth airway generations. Parenchymal tissues beyond the 12th airway generation of each airway path were also analyzed. There was little evidence of visible particle accumulation in the larger conducting airways (generations 2-6), except in bronchial-associated lymphoid tissues and within peribronchial connective tissue. In contrast, terminal and respiratory bronchioles arising from each pathway revealed varying degrees of wall thickening and remodeling. Walls with marked thickening contained moderate to heavy amounts of carbonaceous and mineral dusts. Wall thickening was associated with increases in collagen and interstitial inflammatory cells, including dust-laden macrophages. These changes were significantly greater in first-generation respiratory bronchioles compared to second- and third-generation respiratory bronchioles. These findings suggest that accumulation of carbonaceous and mineral dust in the lungs is significantly affected by lung anatomy with the greatest retention in centers of lung acini. Furthermore, there is significant remodeling of this transitional zone in humans exposed to ambient particulate matter. |
Databáze: | OpenAIRE |
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