POTENTIATION OF DEPRESSOR RESPONSES TO ARACHIDONIC ACID BY ANGIOTENSIN CONVERTING ENZYME INHIBITORS IN THE RAT
| Autor: | S.-C. G. Hui, Soter Dai, Clive W. Ogle |
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| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Physiology Bradykinin Angiotensin-Converting Enzyme Inhibitors Blood Pressure Arachidonic Acids chemistry.chemical_compound Physiology (medical) Internal medicine Renin–angiotensin system medicine Animals Pharmacology Arachidonic Acid biology Chloralose Angiotensin II Drug Synergism Rats Inbred Strains Captopril Angiotensin-converting enzyme Rats Endocrinology chemistry Mechanism of action Enzyme inhibitor biology.protein Arachidonic acid Angiotensin I medicine.symptom circulatory and respiratory physiology medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 11:621-625 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1984.tb00875.x |
| Popis: | SUMMARY 1. In chloralose anaesthetized rats, intravenous administration of captopril, SQ 20881, SA 446 or MK 421 (0.5 mg/kg) potentiated the depressor responses to arachidonic acid 3 mg/kg given intravenously. 2. Same doses of the above angiotensin converting enzyme inhibitors caused an approximately 100-fold decrease in sensitivity to the pressor effects of angiotensin I, with a concomitant similar increase in sensitivity to the depressor effects of bradykinin. 3. Depressor responses to arachidonic acid, both before and after administering the converting enzyme inhibitors, were abolished by intravenous indomethacin (5 mg/kg). 4. These results suggest that increased synthesis of prostaglandins in the circulation may contribute to the hypotensive effect of the angiotensin converting enzyme inhibitors, a group of newly developed antihypertensive agents. |
| Databáze: | OpenAIRE |
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