Randomized controlled trial comparing embryonic quality in rFSH versus hMG in the IVF protocol with GnRH Antagonist
| Autor: | Rita Chapon, Carlos Augusto Bastos de Souza, Vanessa Krebs Genro, João Sabino Cunha-Filho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Single Center law.invention Gonadotropin-Releasing Hormone Randomized controlled trial Ovulation Induction law Pregnancy In vitro fertilization medicine GnRH antagonist Humans Ovarian reserve Randomized Controlled Trials as Topic Gynecology In vitro fertilisation biology business.industry embryonic quality Embryo medicine.disease Recombinant Proteins rFSH HMG-CoA reductase embryonic structures biology.protein Original Article Female Follicle Stimulating Hormone business hMG Embryo quality |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 1517-5693 |
| Popis: | Objective The aim of the present study is to investigate embryo quality (score) after controlled ovarian stimulation for IVF using rFSH or hMG with the GnRH antagonist protocol. Methods Open, randomized, single center study. The patients were randomized to receive rFSH or hMG according to randomized cards inside a black envelope with the name of the respective treatment following a computer generated list (85 patients were allocated to rFSH group and 83 patients to hMG group). Inclusion criteria were patients with IVF indication and normal ovarian reserve. Embryo evaluation was performed on day three, after fertilization based on the Graduated Embryo Score (GES). Results There were no relevant differences in demographic characteristics. There was no difference in pregnancy rates with 27 (31%) and 25 (30.1%) pregnancies for rFSH and hMG, respectively (p=0.87). The total embryo score was the same for both groups, but the best embryo score was significant higher for the rFSH group (77.33±34.0 x 65.07±33.2 p=0.03). The total number of embryos was statistical different, also in favor of the rFSH group (4.17±3.1 x 3.26±2.4 p=0.04). Conclusion The total embryo score was the same for both groups, but the best embryo score was significantly higher for the rFSH group. Moreover, rFSH was associated with an increased number of embryos. |
| Databáze: | OpenAIRE |
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