Stability evaluation of temoporfin-loaded liposomal gels for topical application
| Autor: | Danina Krajišnik, Jela Milić, Mirjana Stupar, Susanna Graefe, Alfred Fahr, Nina Dragicevic-Curic, Sven Winter |
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| Rok vydání: | 2010 |
| Předmět: |
carbomer
Materials science Stereochemistry Administration Topical Dispersity Acrylic Resins Pharmaceutical Science 02 engineering and technology 030226 pharmacology & pharmacy Temoporfin liposomal hydrogel 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phosphatidylcholine Photosensitizer Particle Size Liposome Chromatography Photosensitizing Agents Hydrogels stability 021001 nanoscience & nanotechnology chemistry Mesoporphyrins Photochemotherapy Self-healing hydrogels Liposomes liposome Phosphatidylcholines Chemical stability rheology Particle size 0210 nano-technology Rheology Gels |
| Zdroj: | Journal of Liposome Research |
| Popis: | Temoporfin (mTHPC) is a potent second-generation synthetic photosensitizer. Topical delivery of mTHPC is of great interest for the photodynamic therapy of psoriasis and superficial skin cancer lesions. The aim of this study was to evaluate the stability of hydrophilic gels containing mTHPC-loaded liposomes. Two different mTHPC-loaded liposome dispersions, composed of 15 % (w/w) nonhydrogenated soybean lecithin of different phosphatidylcholine content, were prepared and incorporated (2:1 w/w) into hydrogels of different carbomer concentrations (1.5, 2.25, and 3%; w/w). Obtained liposomal hydrogels, containing 0.15% (w/w) mTHPC, 10% (w/w) phospholipids, and 0, 0.5, or 1% (w/w) carbomer, were analyzed for flow properties, liposome particle size, and polydispersity index (PDI), pH value, and mTHPC content after their preparation and at predetermined time intervals during 6 months of storage at 4 and 23 degrees C. All hydrogels showed, during the whole period of investigation, adequate characteristics for topical application (i.e., they revealed shear-thinning plastic flow behavior). Rheological parameters, particle size, and PDI of liposomes in hydrogels, mTHPC content, and pH value did not show remarkable changes during the storage of gels, which could make them unacceptable for topical use. The obtained results indicated physical and chemical stability of liposomal gels containing mTHPC during 6 months of storage at both temperatures. |
| Databáze: | OpenAIRE |
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