Frequency and predictors of cholesterol target attainment in patients with stable coronary heart disease in Belgium: results from the Dyslipidemia International Study II (DYSIS II CHD)
| Autor: | Ami Vyas, Michel P. Hermans, Dominik Lautsch, Martin Horack, Luc Missault, Dieuwke De Keyzer, Olivier S. Descamps, Anselm K. Gitt, Baishali M. Ambegaonkar, Philippe Brudi, Bernard Gillot, Sofie Gevaert |
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| Přispěvatelé: | UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service d'endocrinologie et de nutrition |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Medication Therapy Management Coronary Disease Comorbidity Health Services Misuse 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sex Factors Belgium Internal medicine medicine Diabetes Mellitus Humans LDL-cholesterol In patient 030212 general & internal medicine Lipoprotein cholesterol Aged Hypolipidemic Agents Dyslipidemias Ldl cholesterol Cholesterol business.industry Statins General Medicine Cholesterol LDL Middle Aged medicine.disease Cardiovascular disease Coronary heart disease chemistry 030220 oncology & carcinogenesis Target attainment Cardiology Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Dyslipidemia |
| Zdroj: | Acta Clinica Belgica, Vol. 74, no. 6, p. 399-404 (2019) |
| Popis: | OBJECTIVES: To document the frequency and predictors of low-density lipoprotein cholesterol (LDL-C) target value attainment among patients with coronary heart disease (CHD) in Belgium. METHODS: The second Dyslipidemia International Study (DYSIS II) was an observational study of the prevalence of dyslipidemias and lipid target value attainment. Patients in this analysis were aged ≥ 18, had documented CHD, and had a full lipid profile. Use of lipid-lowering therapy (LLT), lipid profile, and LDL-C target value attainment (< 70 mg/dL) were assessed cross-sectionally at the enrollment visit. The distribution of LLTs was assessed among treated patients. Multivariate logistic regression was used to identify variables predictive of LDL-C target value attainment in treated patients. RESULTS: We identified 409 patients with CHD in Belgium, 387 (94.6%) of whom were on LLT at the time of the lipid profile. Among treated patients, the rate of LDL-C target value attainment was 40.6%, and statin monotherapy was the most commonly used LLT (79.3%). Among users of statin monotherapy or combination therapy, simvastatin was the most commonly used treatment (41.6% of patients). Diabetes was associated with higher odds of LDL-C target value attainment (OR 2.29, 95% CI 1.33-3.93), and female gender was associated with lower odds (OR 0.48, 95% CI 0.24-0.97). CONCLUSION: Rates of LDL-C target value attainment are low in patients with CHD in Belgium. Intensifying statin therapy or combining it with non-statins is essential in Belgian patients for optimal LDL-C reduction. |
| Databáze: | OpenAIRE |
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