Serum activity of MMP-2 and MMP-9 and stromielisin-1 concentration as predictors in the pathogenesis of bronchopulmonary dysplasia in preterm neonates
| Autor: | Joanna Kocot, Jarosław Bryda, Sławomir Wątroba, Jacek Kurzepa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty business.industry stromielisin-1 05 social sciences lcsh:R matrix metalloproteinases lcsh:Medicine Matrix metalloproteinase medicine.disease Gastroenterology Pathogenesis 03 medical and health sciences 0302 clinical medicine Infectious Diseases Bronchopulmonary dysplasia Internal medicine 0502 economics and business bronchopulmonary dysplasia medicine 050211 marketing tissue inhibitors of metalloproteinases preterm infants business 030217 neurology & neurosurgery |
| Zdroj: | Postępy Higieny i Medycyny Doświadczalnej, Vol 73, Pp 703-712 (2019) |
| ISSN: | 1732-2693 0032-5449 |
| Popis: | Aim: Bronchopulmonary dysplasia (BPD) is one of the most severe respiratory diseases, mainly related to premature neonates. Previous studies indicated the role of matrix metalloproteinases (MMPs) in the development of BPD. The aim of the study was to determine the relationship between MMP-2, MMP-3, MMP-9 with their tissue inhibitors (TIMP-1 TIMP-2) and BPD occurrence in premature neonates. Material/Methods: Eighty-one patients, divided into four study groups, numbered from 1 to 4, depending on gestational age (25–28; 29–32; 33–36; 37–40 weeks), were enrolled. Venous blood was collected between 5 and 7 days after birth. The activity of MMP-2 and MMP-9 were determined with usage of gelatin zymography, whereas MMP-3, TIMP-1 and TIMP-2 was determined using the immunoassay ELISA. Results: BPD was diagnosed in 50% of patients from group 1 and 11% from group 2. The increase of MMP-2 activity in Group 2, and a decrease in MMP-2/TIMP-2 ratio was noticed in Group 1 compared to Group 2 and 4. A significantly lower incidence of BPD in patients with higher (above the median) values for MMP-2/TIMP-2 (OR = 0.02, CI = 0.00 – 0.55; p |
| Databáze: | OpenAIRE |
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