Biocatalysis in drug discovery and development
| Autor: | Paul N. Devine, Anna Fryszkowska |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Engineering Indoles Alkylation Drug Industry Chemistry Pharmaceutical 010402 general chemistry Protein Engineering 01 natural sciences Biochemistry Analytical Chemistry 03 medical and health sciences Drug Discovery Transition Elements Pyrroles Biotransformation Pharmaceutical industry business.industry Drug discovery Stereoisomerism Directed evolution Photochemical Processes 0104 chemical sciences Enzymes 030104 developmental biology Pyrimidines Biocatalysis Metals Pharmaceutical manufacturing Biochemical engineering business Peptides Oxidation-Reduction |
| Zdroj: | Current opinion in chemical biology. 55 |
| ISSN: | 1879-0402 |
| Popis: | Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is beginning to transform chemical synthesis in the pharmaceutical industry. This review presents recent examples of the creative use of biocatalysis to enable drug discovery and development. We illustrate how increased access to novel biotransformations and the rise of cascade biocatalysis allowed fundamentally new syntheses of novel medicines, representing progress toward more sustainable pharmaceutical manufacturing. Finally, we describe the opportunities and challenges the industry must address to ensure the reduction to practice of biotechnological innovations to develop new therapies in a faster, more economical, and environmentally benign way. |
| Databáze: | OpenAIRE |
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