Vaginal lactoferrin in asymptomatic patients at low risk for pre-term labour for shortened cervix: Cervical length and interleukin-6 changes
| Autor: | Giovanni Nazzaro, Mariavittoria Locci, M. Miranda, Stefania Montagnani, Clotilde Castaldo, G. De Placido, Ernesto Salzano |
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| Přispěvatelé: | Locci, Mariavittoria, Nazzaro, Giovanni, Miranda, Marilena, E., Salzano, Montagnani, Stefania, Castaldo, Clotilde, DE PLACIDO, Giuseppe |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Cervix Uteri Asymptomatic Obstetric Labor Premature Anti-Infective Agents Pregnancy Animals PRETERM LABOUR Medicine Longitudinal Studies Prospective Studies Interleukin 6 Cervix Cervical length Regular Uterine Contraction Vaginal Smears Inflammation biomarkers biology Interleukin-6 Lactoferrin business.industry Obstetrics Obstetrics and Gynecology Administration Intravaginal medicine.anatomical_structure Cervical Length Measurement biology.protein Gestation Cattle Female medicine.symptom business Biomarkers |
| Zdroj: | Journal of Obstetrics and Gynaecology. 33:144-148 |
| ISSN: | 1364-6893 0144-3615 |
| DOI: | 10.3109/01443615.2012.740527 |
| Popis: | A total of 3,324 singleton pregnant women were screened for pre-term delivery and 128 women were finally randomised and analysed for outcome showing borderline cervical length (25-29 mm) and elevated cervico-vaginal interleukin 6 levels. To verify if vaginal administration of lactoferrin might have an influence on these variables, two groups of 64 patients were formed. Study cases were submitted to lactoferrin for 21 days; controls received no treatment. An inverse relation was found between interleukin 6 levels and cervical length. On day 30 from the beginning of the treatment, study cases showed a decrease in interleukin 6 levels and an increase in cervical length. A greater number of women with regular uterine contractions and reduced cervical consistency before the 37th week of gestation were found in the controls. Our data show that lactoferrin could play a role in reducing the number of women at risk for pre-term birth for shortened cervical length and elevated interleukin 6 levels. |
| Databáze: | OpenAIRE |
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