Highly pathogenic avian influenza H5N1 Clade 2.3.2.1c virus in migratory birds, 2014–2015

Autor: Mingxin Li, Alexander Shestopalov, Yingxia Liu, Ivan Susloparov, Zhenjie Zhang, Zhi Xing, Fumin Lei, Lei Liu, Wenjun Liu, Gary Wong, Di Liu, Jianjun Chen, Yuhai Bi, George F. Gao, Tianlong Cai, Jianqing Sun, Weifeng Shi, Yubang He, Kirill Sharshov
Rok vydání: 2016
Předmět:
Zdroj: Virol Sin
ISSN: 1995-820X
1674-0769
DOI: 10.1007/s12250-016-3750-4
Popis: A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-origin. The Clade 2.3.2.1c H5N1 reassortants displayed a high genetic relationship to a human H5N1 strain (A/Alberta/01/2014). Further analysis showed that similar viruses have been circulating in wild birds in China, Russia, Dubai (Western Asia), Bulgaria and Romania (Europe), as well as domestic poultry in some regions of Africa. The affected areas include the Central Asian, East Asian-Australasian, West Asian-East African, and Black Sea/Mediterranean flyways. These results show that the novel Clade 2.3.2.1c reassortant viruses are circulating worldwide and may have gained a selective advantage in migratory birds, thus posing a serious threat to wild birds and potentially humans. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s12250-016-3750-4 and is accessible for authorized users.
Databáze: OpenAIRE
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