Evaluation of Wound Healing Potential of New Composite Liposomal Films Containing Coenzyme Q10 and D-Panthenyl Triacetate as Combinational Treatment

Autor: Abdurrahim Kocyigit, Burak Çelik, Eray Metin Guler, Ali Asram Sağıroğlu, Özgen Özer
Přispěvatelé: ASRAM SAĞIROĞLU, ALİ, Ege Üniversitesi
Rok vydání: 2021
Předmět:
liposomal films
Keratinocytes
Swine
Ubiquinone
d-panthenyl triacetate
Administration
Topical
Chemistry
Pharmaceutical
Pharmacology toxicology
Composite number
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
Cell Line
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Animals
Humans
Sağıroğlu A. A.
Çelik B.
Güler E. M.
Koçyiğit A.
Özer Ö.
-Evaluation of Wound Healing Potential of New Composite Liposomal Films Containing Coenzyme Q10 and D-Panthenyl Triacetate as Combinational Treatment.-
Pharmaceutical development and technology
ss.1-23
2021
Particle Size
Skin
Coenzyme Q10
Liposome
Wound Healing
integumentary system
Regeneration (biology)
fungi
food and beverages
General Medicine
topical administration
Fibroblasts
021001 nanoscience & nanotechnology
Drug Liberation
chemistry
Liposomes
0210 nano-technology
Wound healing
Biomedical engineering
Popis: Conventional formulations can not achieve wound healing efficiently and fail to accelerate wound regeneration. To overcome these problems, it was planned to develop nanoformulations that perform a positive effect on the wound healing duration and are suitable for topical use. in this study, liposomal film formulations that encapsulated d-panthenyl triacetate (PTA) and coenzyme Q10 (CoQ10) were optimized by using response surface methodology (RSM) and were analyzed for their wound healing efficacy and cytotoxicity on fibroblast (CCD1079 Sk) and keratinocyte (HEKa) cells. Swelling index, puncture strength, and puncture deformation values, which were choosen as dependent variables for the liposomal film formulation were found as 556.9% +/- 21.3, 3.98 +/- 0.98 N/mm(2), and 6.57% +/- 1.12, respectively. Cumulative release of 65.32% for PTA and 12.23% for CoQ10 was obtained after 24 hours of in vitro release study in sink conditions. The in vitro cytotoxicity and wound healing assay results suggested that optimum formulation could be used safely on fibroblast and keratinocyte cells and provided wound closure entirely after 24 h. Consequently, the optimum liposomal film containing PTA and CoQ10 formulations could be proposed as an innovative approach in wound healing treatment, considering their release, mechanical properties, stability, and effectiveness.
Bezmialem Vakif University Research FundBezmialem Vakif University [2.2018/1]
This study was supported by Bezmialem Vakif University Research Fund [Grant number 2.2018/1].
Databáze: OpenAIRE
Externí odkaz: