Association between murine double minute 2 T309G polymorphism and risk of liver cancer
| Autor: | Zhiying Yang, Tao Tang, Wen-Yue Wang, Xin Song, Haidong Tan, Lin-ping Huang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Polymorphism Genetic business.industry Liver Neoplasms Case-control study Subgroup analysis Proto-Oncogene Proteins c-mdm2 General Medicine Odds ratio medicine.disease Bioinformatics Prognosis Gastroenterology Confidence interval Meta-Analysis as Topic Risk Factors Internal medicine Case-Control Studies medicine Humans Genetic Predisposition to Disease Liver cancer business |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(11) |
| ISSN: | 1423-0380 |
| Popis: | During the past decade, a number of studies were published to evaluate the association between murine double minute 2 (MDM2) T309G polymorphism and risk of liver cancer. However, the association between MDM2 T309G polymorphism and risk of liver cancer was still unclear owing to the conflicting results from those published studies. An undated meta-analysis of all eligible studies was carried out to comprehensively assess the association. The pooled odds ratio (OR) with 95 % confidence interval (95% CI) was used to evaluate the association between MDM2 T309G polymorphism and risk of liver cancer. Finally, ten studies with a total of 2,243 cases and 3,471 controls were finally included into the meta-analysis. Overall, there was an association between MDM2 T309G polymorphism and risk of liver cancer (G vs. T: OR=1.39, 95% CI 1.17-1.64, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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