Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography
| Autor: | Albert Roque, Juhani Knuuti, Gualtiero Pelosi, María Nazarena Pizzi, Silvia Rocchiccioli, Oberdan Parodi, Anna Teresinska, Jeff M. Smit, Ronny R. Buechel, Alexander R. van Rosendael, Bart Mertens, Danilo Neglia, Rosa Poddighe, Antti Saraste, Arthur J.H.A. Scholte, Chiara Caselli, Mohammed El Mahdiui |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Time Factors Coronary Angiography Severity of Illness Index Coronary artery disease male Risk Factors Diabetes mellitus Coronary plaque medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Risk factor Computed tomography angiography medicine.diagnostic_test business.industry Coronary computed tomography angiography Middle Aged Prognosis medicine.disease Coronary Vessels Plaque Atherosclerotic risk factor diabetes mellitus Disease Progression Female Radiology Cardiology and Cardiovascular Medicine business computed tomography angiography coronary artery disease Follow-Up Studies |
| Zdroj: | Circulation. Cardiovascular imaging 13 (2020). doi:10.1161/CIRCIMAGING.119.009750 info:cnr-pdr/source/autori:Smit J. M.; van Rosendael A. R.; El Mahdiui M.; Neglia D.; Knuuti J.; Saraste A.; Buechel R. R.; Teresinska A.; Pizzi M. N.; Roque A.; Poddighe R.; Mertens B. J.; Caselli C.; Rocchiccioli S.; Parodi O.; Pelosi G.; Scholte A. J./titolo:Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography/doi:10.1161%2FCIRCIMAGING.119.009750/rivista:Circulation. Cardiovascular imaging/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:13 Circulation: Cardiovascular Imaging, 13(3). LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.119.009750 |
| Popis: | Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CTA. The primary end point was coronary artery disease progression, defined as the absolute annual increase in total, calcified, and noncalcified plaque volume by quantitative CTA analysis. Results In total, 202 patients underwent serial coronary CTA with a mean interscan period of 6.2±1.4 years. On a per-plaque basis, increasing age (β=0.070; P =0.058) and hypertension (β=1.380; P =0.075) were nonsignificantly associated with annual total plaque progression. Male sex (β=1.676; P =0.009), diabetes mellitus (β=1.725; P =0.012), and statin use (β=1.498; P =0.046) showed an independent association with annual progression of calcified plaque. While hypertension (β=2.259; P =0.015) was an independent determinant of noncalcified plaque progression, statin use (β=−2.178; P =0.050) was borderline significantly associated with a reduced progression of noncalcified plaque. Conclusions Statin use was associated with an increased progression of calcified coronary plaque and a reduced progression of noncalcified coronary plaque, potentially reflecting calcification of the noncalcified plaque component. Whereas hypertension was the only modifiable risk factor predictive of noncalcified plaque progression, diabetes mellitus mainly led to an increase in calcified plaque. These findings could yield the need for intensified preventive treatment of patients with diabetes mellitus and hypertension to slow and stabilize coronary artery disease progression and improve clinical outcome. |
| Databáze: | OpenAIRE |
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