Cortical pattern generation during dexterous movement is input-driven
| Autor: | Brett D. Mensh, Nakul Verma, Adam W. Hantman, Britton Sauerbrei, Mayank Kabra, Matteo Mischiati, Jian-Zhong Guo, Wendy W Guo, Jeremy D. Cohen, Kristin Branson |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male animal structures Movement Thalamus Biology Article 03 medical and health sciences Mice 0302 clinical medicine Text mining Digital pattern generator medicine Animals Axon Multidisciplinary Behavior Animal business.industry General Neuroscience Motor Cortex Pattern generation 030104 developmental biology medicine.anatomical_structure Female Forelimb business Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Nature |
| ISSN: | 1476-4687 |
| Popis: | The motor cortex controls skilled arm movement by sending temporal patterns of activity to lower motor centres1. Local cortical dynamics are thought to shape these patterns throughout movement execution2-4. External inputs have been implicated in setting the initial state of the motor cortex5,6, but they may also have a pattern-generating role. Here we dissect the contribution of local dynamics and inputs to cortical pattern generation during a prehension task in mice. Perturbing cortex to an aberrant state prevented movement initiation, but after the perturbation was released, cortex either bypassed the normal initial state and immediately generated the pattern that controls reaching or failed to generate this pattern. The difference in these two outcomes was probably a result of external inputs. We directly investigated the role of inputs by inactivating the thalamus; this perturbed cortical activity and disrupted limb kinematics at any stage of the movement. Activation of thalamocortical axon terminals at different frequencies disrupted cortical activity and arm movement in a graded manner. Simultaneous recordings revealed that both thalamic activity and the current state of cortex predicted changes in cortical activity. Thus, the pattern generator for dexterous arm movement is distributed across multiple, strongly interacting brain regions. |
| Databáze: | OpenAIRE |
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