Paraquat Induces Apoptosis through Cytochrome C Release and ERK Activation
| Autor: | Hong Joo Seo, Jung-Hee Lee, Sang Joon Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
MAPK/ERK pathway
inorganic chemicals Paraquat Erk signaling Apoptosis Bioinformatics Biochemistry NIH3T3 cells chemistry.chemical_compound Drug Discovery Extracellular Medicine heterocyclic compounds Protein kinase A Pharmacology chemistry.chemical_classification Reactive oxygen species biology ERK1/2 business.industry Cytochrome c Cytochrome C MAPK Cell biology chemistry biology.protein Molecular Medicine Original Article business |
| Zdroj: | Biomolecules & Therapeutics |
| ISSN: | 2005-4483 1976-9148 |
| Popis: | Paraquat has been suggested to induce apoptosis by generation of reactive oxygen species (ROS). However, little is known about the mechanism of paraquat-induced apoptosis. Here, we demonstrate that extracellular signal-regulated protein kinase (ERK) is required for paraquat-induced apoptosis in NIH3T3 cells. Paraquat treatment resulted in activation of ERK, and U0126, inhibitors of the MEK/ERK signaling pathway, prevented apoptosis. Moreover, paraquat-induced apoptosis was associated with cytochrome C release, which could be prevented by treatment with the MEK inhibitors. Taken together, our findings suggest that ERK activation plays an active role in mediating paraquat-induced apoptosis of NIH3T3 cells. |
| Databáze: | OpenAIRE |
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