Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in Aspergillus nidulans. J. Fungi 2021, 7, 560
| Autor: | Ignacio Bravo Plaza, Miguel A Penalva, Miguel Hernandez-Gonzalez |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Comunidad de Madrid, Bravo-Plaza, Ignacio, Hernández-González, Miguel, Peñalva, Miguel Ángel, Bravo-Plaza, Ignacio [0000-0003-0934-9084], Hernández-González, Miguel [0000-0001-7445-314X], Peñalva, Miguel Ángel [0000-0002-3102-2806] |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Fungi Digital.CSIC. Repositorio Institucional del CSIC instname Journal of Fungi, Vol 7, Iss 1037, p 1037 (2021) |
| ISSN: | 2309-608X |
| Popis: | 7 p.-1 fig.-1 tab. Contrary to the opinion recently offered by Dimou et al., our previously published biochemical, subcellular and genetic data supported our contention that AN11127 corresponds to the A. nidulans gene encoding Sec12, which is the guanine nucleotide exchange factor (GEF) specific for SAR1. We add here additional bioinformatics evidence that fully disprove the otherwise negative evidence reported by Dimou et al., highlighting the dangers associated with the lax interpretation of genomic data. On the positive side, we establish guidelines for the identification of this key secretory gene in other species of Ascomycota and Basidiomycota, including species of medical and applied interest. This work was supported by Spain’s ‘Ministerio de Ciencia, Innovación y Universidades’ (MCIU/AEI/FEDER, UE) grants BIO2015-65090R and RTI2018-093344-B-I00 to M.A.P.; and by grant S2017/BMD-3691 InGEMICS-CM funded by the Comunidad de Madrid (Spain) and European Structural and Investment Funds. |
| Databáze: | OpenAIRE |
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