Accuracy of FDG-PET/CT and paraneoplastic antibodies in diagnosing cancer in paraneoplastic neurological syndromes

Autor: Haluk Sayman, Sertac Asa, Kerim Sonmezoglu, Metin Halac, Sait Sager, S. Yilmaz Aksoy, Betül Vatankulu
Rok vydání: 2015
Předmět:
Male
Pathology
Fluorine Radioisotopes
Antibodies
Neoplasm
Diagnostic accuracy
030218 nuclear medicine & medical imaging
0302 clinical medicine
Positron Emission Tomography Computed Tomography
Medicine
General Environmental Science
Aged
80 and over
biology
medicine.diagnostic_test
Lymphoma
Non-Hodgkin
General Engineering
RNA-Binding Proteins
Middle Aged
ELAV Proteins
Positron emission tomography
Fdg pet ct
Female
Antibody
Paraneoplastic Syndromes
Nervous System
Adult
medicine.medical_specialty
animal structures
Adolescent
Nerve Tissue Proteins
Malignancy
Sensitivity and Specificity
03 medical and health sciences
Young Adult
Fluorodeoxyglucose F18
Predictive Value of Tests
Neuro-Oncological Ventral Antigen
Carcinoma
Humans
Radiology
Nuclear Medicine and imaging
In patient
Aged
Autoantibodies
Retrospective Studies
business.industry
Cancer
Retrospective cohort study
medicine.disease
nervous system
biology.protein
General Earth and Planetary Sciences
sense organs
Radiopharmaceuticals
business
Nuclear medicine
030217 neurology & neurosurgery
Zdroj: Revista espanola de medicina nuclear e imagen molecular. 35(1)
ISSN: 2253-8070
Popis: Objective There is still no consensus about whether to perform PET/CT to detect carcinoma in paraneoplastic neurological syndromes (PNS) in patients with or without antibodies. The aim of this study is to determine the diagnostic accuracy of PET/CT and antibodies in patients with PNS. Material and Methods A retrospective study was conducted on patients with clinically suspected PNS between 2008 and 2013. The association between histopathological findings, paraneoplastic antibodies, and PET/CT findings were evaluated. Sensitivity and specificity for the detection of underlying malignancy were calculated for PET/CT and paraneoplastic antibodies. Results A total of 42 patients were analyzed. Of these 42 patients, 32 (75%) had a classical PNS, 6 (14%) had positive PET/CT findings, and 34 were tested for the presence of antibodies (anti-Hu Ab, anti-Yo Ab, and anti-Ri Ab). Twenty one of 34 patients had positive antibodies. Of the 6 patients with positive PET/CT findings, 6 had positive histopathological results. Among 21 patients with positive biomarkers, carcinoma was confirmed only in 5 patients. One patient with negative antibodies, but positive PET/CT findings, was diagnosed with a tumor. Gastric carcinoma was detected in 1 patient with negative PET/CT findings and antibodies during follow-up. Based on the results, PET/CT was found to have 85.71% sensitivity, 100% specificity, 100% positive and 97.22% negative predictive values in the detection of tumors. Conclusion PET/CT has a certain diagnostic accuracy for detecting underlying malignancy in patients with PNS, regardless of the presence of paraneoplastic antibodies.
Databáze: OpenAIRE
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