Plasma prolactin response to domperidone in acute schizophrenia and schizophreniform illness
| Autor: | Armando Magnani, Gaetano Frajese, Herbert Y. Meltzer, Elena Scaramucci, Costanzo Moretti, Dina Nerozzi, Marco Cerilli, Vincenzo Sforza, Italo Antonozzi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Psychosis Receptors Dopamine Basal (phylogenetics) Dopamine Internal medicine Dopamine receptor D2 medicine Humans Biological Psychiatry business.industry Receptors Dopamine D2 Receptors Dopamine D1 Dopamine antagonist Brain medicine.disease Prolactin Domperidone Psychiatry and Mental health Endocrinology Military Personnel Psychotic Disorders Schizophrenia Acute Disease Schizophrenic Psychology business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Psychiatry research. 34(2) |
| ISSN: | 0165-1781 |
| Popis: | The prolactin (PRL) response to 20 mg of domperidone, a peripheral dopamine (DA) blocking agent, was evaluated in a group of 16 drug-free, acute, young schizophreniform and schizophrenic males and in a group of age-matched normal males. Although basal plasma PRL levels were normal, the PRL responses following domperidone were blunted in both patient groups. The PRL response was more blunted in the schizophreniform patients than in the schizophrenic patients. Possible explanations for these results include pharmacokinetic factors or abnormalities of the pituitary D2 DA receptors. |
| Databáze: | OpenAIRE |
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