Increased Oxidative Damage Associated with Unfavorable Cytogenetic Subgroups in Chronic Lymphocytic Leukemia
| Autor: | David Ivars, Rosa Collado, Guillermo T. Sáez, Mercedes Egea, Á Miguel, Isabel Oliver, Carmen Tormos, Felix Carbonell |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Genome instability Article Subject DNA Repair DNA damage DNA repair Chronic lymphocytic leukemia lcsh:Medicine Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Cohort Studies chemistry.chemical_compound Malondialdehyde medicine Humans Lymphocytes In Situ Hybridization Fluorescence Aged Aged 80 and over Chromosome Aberrations General Immunology and Microbiology medicine.diagnostic_test lcsh:R Deoxyguanosine General Medicine Glutathione Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Oxidative Stress chemistry 8-Hydroxy-2'-Deoxyguanosine Immunology Female Lipid Peroxidation Reactive Oxygen Species Gene Deletion Oxidative stress DNA Damage Research Article Fluorescence in situ hybridization |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| DOI: | 10.1155/2014/686392 |
| Popis: | Oxidative stress contributes to genomic instability in chronic lymphocytic leukemia (CLL), but its relationship with the acquisition of specific chromosomal abnormalities is unknown. We recruited 55 untreated CLL patients and assessed 8-oxo-2′-deoxyguanosine (8-oxo-dG), glutathione, and malondialdehyde (MDA) levels, and we compared them among the cytogenetic subgroups established using fluorescence in situ hybridization (FISH). Significant increases in 8-oxo-dG and/or MDA were observed in patients with unfavorable cytogenetic aberrations (17p and 11q deletions) compared to the 13q deletion group.TP53deletion patients exhibited a diminished DNA repair efficiency. Finally, cases with normal FISH also showed enhanced 8-oxo-dG, which could result in adverse outcomes. |
| Databáze: | OpenAIRE |
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