Induced pluripotent stem cells and hepatic differentiation
| Autor: | Shou-Dong Lee, Kai Hsi Lu, Yueh Chien, Chih Hung Chiang, Cho Chin Sun, Teh Ia Huo, Jung Hung Hsieh |
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| Rok vydání: | 2013 |
| Předmět: |
Medicine(all)
Genetics lcsh:R5-920 Somatic cell Regeneration (biology) Induced Pluripotent Stem Cells hepatic repair Cell Differentiation General Medicine Germ layer Embryoid body Biology Embryonic stem cell Cell biology Liver Humans Stem cell lcsh:Medicine (General) Induced pluripotent stem cell Reprogramming |
| Zdroj: | Journal of the Chinese Medical Association, Vol 76, Iss 11, Pp 599-605 (2013) |
| ISSN: | 1728-7731 |
| Popis: | Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to a pluripotent state by the introduction of specific factors. They can be generated from cells of different origins, such as fibroblasts, keratinocytes, hepatocytes, and blood. iPSCs are similar to embryonic stem cells (ESCs) in several aspects, such as morphology, expression of pluripotency markers, and the ability to develop teratoma that contains tissue from three germ layers. In addition, iPSCs can undergo tridermal differentiation, including hepatic specific lineages. Considering that iPSCs could be a source of hepatocyte regeneration, iPSC-based therapy has been widely implicated in the treatment of liver disease and hepatic regeneration. In the present review, we discuss the therapeutic potential of iPSCs in hepatic repair and focus on the clinical applications of iPSCs. |
| Databáze: | OpenAIRE |
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