Noninvasive assessment of Crohn's disease intestinal lesions with (18)F-FDG PET/CT
| Autor: | Roland Hustinx, Jacques Belaiche, Edouard Louis, Geoffrey Ancion, Veronique Spote, Arnaud Colard |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Colon Gastroenterology Feces Crohn Disease Fluorodeoxyglucose F18 Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Aged Gastrointestinal tract Crohn's disease medicine.diagnostic_test business.industry Middle Aged medicine.disease Crohn's Disease Activity Index Confidence interval Endoscopy Intestines C-Reactive Protein Positron emission tomography Positron-Emission Tomography Female Calprotectin Radiopharmaceuticals business Tomography X-Ray Computed Leukocyte L1 Antigen Complex |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 48(7) |
| ISSN: | 0161-5505 |
| Popis: | Pilot studies have shown good sensitivity and specificity for 18F-FDG PET in detecting gastrointestinal lesions of Crohn9s disease. The combination of 18F-FDG PET with CT may further improve the localization and characterization of lesions with increased 18F-FDG uptake. Our aim was to assess the use of 18F-FDG PET/CT in evaluating the activity and location of Crohn9s disease along the gastrointestinal tract. Methods: After giving informed consent, 22 patients with Crohn9s disease were prospectively studied. They underwent 18F-FDG PET/CT, followed by ileocolonoscopy within 1 wk (mean, 2 d). The Crohn9s disease activity index (CDAI) was calculated, and serum C-reactive protein (CRP) and fecal calprotectin were measured before endoscopy. The Crohn9s disease endoscopy index of severity (CDEIS) was calculated during endoscopy. The global CDEIS score and endoscopic subscores for various ileocolonic segments were used for analysis. Results: Globally, 95 intestinal and colonic segments in 22 patients were analyzed. 18F-FDG PET/CT detected 35 of 48 endoscopically affected segments (sensitivity for the detection of endoscopic lesions, 72.9%). The sensitivity of 18F-FDG PET/CT for the detection of severe endoscopic lesions (deep ulcers and strictures) was 100% (14/14). The global PET/CT score significantly correlated with CDEIS (r = 0.51; 95% confidence interval [CI], 0.09–0.77; P = 0.017), CDAI (r = 0.58; 95% CI, 0.17–0.80; P = 0.005), and CRP (r = 0.56; 95% CI, 0.19–0.81; P = 0.007). Conclusion:18F-FDG PET/CT was globally well correlated to the clinical, endoscopic, and biologic activity of Crohn9s disease. Above all, this technique had a good sensitivity for the detection of intestinal and colonic segments with moderate to severe mucosal lesions. The potential impact of this promising tool on the global management of patients with Crohn9s disease should be further evaluated in prospective studies. |
| Databáze: | OpenAIRE |
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