No Increase of Blocking Type Anti-Thyrotropin Receptor Antibodies During Pregnancy in Patients with Graves’ Disease
| Autor: | Yukiko Izumi, Yukiko Nakata, Yoh Hidaka, Nobuyuki Amino, Keiko Takeoka, Atsuo Nagata, Toru Takano, Ke-ita Tatsumi |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Biochemistry Thyrotropin receptor Endocrinology Pregnancy Immunopathology Internal medicine Blocking antibody medicine Humans Autoantibodies Autoimmune disease business.industry Postpartum Period Biochemistry (medical) Gestational age Receptors Thyrotropin medicine.disease Graves Disease eye diseases Pregnancy Complications Gestation Female business Immunoglobulins Thyroid-Stimulating |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 88:5871-5874 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2003-030971 |
| Popis: | Serial changes in serum levels of anti-TSH receptor antibodies were examined during and after pregnancy in six patients with Graves' disease receiving no or minimal maintenance doses of antithyroid drugs. During pregnancy, serum levels of TSH-binding inhibitory Igs (P < 0.001) and thyroid-stimulating antibodies (TSAbs) (P < 0.01) decreased gradually but increased after delivery in all patients. Activities of thyroid-stimulation blocking antibodies (TSBAbs) were lower than the cut-off value in early pregnancy, and values significantly decreased in four patients during pregnancy. The other two patients showed no significant change during pregnancy. In contrast, TSBAb levels increased significantly (P < 0.01) after delivery in all patients. We found that activities of TSH-binding inhibitory Igs, TSAb, and TSBAb decrease during pregnancy and increase after delivery, suggesting that amelioration of Graves' disease during pregnancy is induced by decrease of TSAb but not by the appearance of TSBAb. |
| Databáze: | OpenAIRE |
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