Mucosal-associated invariant T cells in autoimmune and immune-mediated diseases
| Autor: | Agnès Lehuen, Ophélie Rouxel |
|---|---|
| Přispěvatelé: | Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'excellence Inflamex, Sorbonne Paris Cité, Lehuen, Agnès |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
mediated-immune diseases [SDV.IMM] Life Sciences [q-bio]/Immunology Autoimmune diseases Immunology Inflammation Mucosal associated invariant T cell Biology Mucosal-Associated Invariant T Cells Proinflammatory cytokine Pathogenesis 03 medical and health sciences Immune system medicine Immunology and Allergy Animals Humans INSERM 1016 MAIT Cells Cell Biology 3. Good health 030104 developmental biology Immune System Diseases mucosal-associated invariant T cells Correspondence Agn es Lehuen inflammation [SDV.IMM]Life Sciences [q-bio]/Immunology medicine.symptom innate T cells Homing (hematopoietic) Tissue inflammation |
| Zdroj: | Immunology and Cell Biology Immunology and Cell Biology, Nature Publishing Group, 2018, 96 (6), pp.618-629. ⟨10.1111/imcb.12011⟩ Immunology and Cell Biology, 2018, 96 (6), pp.618-629. ⟨10.1111/imcb.12011⟩ |
| ISSN: | 0818-9641 1440-1711 |
| DOI: | 10.1111/imcb.12011⟩ |
| Popis: | International audience; Autoimmune and inflammatory diseases have complex etiologies not fully understood. Both innate and adaptive immune cells are involved in the pathogenesis of these diseases. Mucosal-associated invariant T (MAIT) cells express an invariant TCRa chain (Va7.2-Ja33 in humans and Va19-Ja33 in mice) and recognize the conserved MHC-I-related molecule MR1 presenting bacterial metabolites derived from the synthesis of vitamin B. MAIT cells harbor tissue homing properties and produce inflammatory cytokines, suggesting that MAIT cells may play a key role in autoimmune and inflammatory diseases. In this review, we described the current knowledge on MAIT cells in these pathologies, based on patients analyses as well as mouse models. While most of the studies support a deleterious role of MAIT cells in tissue inflammation and destruction, a few reports suggest a protective role of MAIT cells. MAIT cells could represent a new biomarker of disease progression, and a better knowledge of their function might open new avenues for therapeutic strategies based on their manipulation. |
| Databáze: | OpenAIRE |
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