The Metabolism of Intravenously Administered Iron-Dextran
| Autor: | A. Jacobs, K. Kanakakorn, I. Cavill |
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| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Iron Chromatography DEAE-Cellulose Internal medicine medicine Iron deficient Humans Iron dextran Mononuclear Phagocyte System chemistry.chemical_classification Iron Radioisotopes Plasma samples Chemistry Transferrin Hematology Mononuclear phagocyte system Metabolism Plasma levels Clearance time Endocrinology Biochemistry Injections Intravenous Female Iron-Dextran Complex Half-Life Protein Binding |
| Zdroj: | British Journal of Haematology. 25:637-643 |
| ISSN: | 1365-2141 0007-1048 |
| Popis: | Summary. A method is described for the separation of transferrin iron and iron-dextran in plasma samples. Estimation of plasma levels following the intravenous administration of labelled iron-dextran showed that the mean half clearance time was 5.9 hr. About 40% of the injected dose of iron in circulation was bound to transferrin 11 hr later and there was no difference between normal and iron deficient subjects in the rate of iron release by the reticuloendothelial system. The results indicate a need to re-evaluate present concepts of reticuloendothelial iron metabolism. |
| Databáze: | OpenAIRE |
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