Metabolic distress in lipid & one carbon metabolic pathway through low vitamin B-12: a population based study from North India

Autor: Priyanka Rani Garg, Shipra Joshi, Suniti Yadav, Kallur Nava Saraswathy
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Homocysteine
Vitamin B-12
Endocrinology
Diabetes and Metabolism
Cholesterol
VLDL
Clinical Biochemistry
Physiology
030204 cardiovascular system & hematology
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Under-nutrition
lcsh:RC620-627
education.field_of_study
Middle Aged
Lipid
Vitamin B 12
lcsh:Nutritional diseases. Deficiency diseases
Metabolic pathway
Female
Waist Circumference
Adult
Vitamin
Population
Hyperhomocysteinemia
India
030209 endocrinology & metabolism
Clinical nutrition
03 medical and health sciences
Folic Acid
Diabetes mellitus
medicine
Humans
Obesity
Vitamin B12
education
Triglycerides
Dyslipidemias
business.industry
Research
Cholesterol
HDL
Biochemistry (medical)
Vitamin B 12 Deficiency
Cholesterol
LDL
medicine.disease
Cross-Sectional Studies
chemistry
business
Dyslipidemia
Zdroj: Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-8 (2018)
Lipids in Health and Disease
DOI: 10.1186/s12944-018-0748-y
Popis: Background Dyslipidemia and hyper-homocysteinemia are the major independent risk factors of cardio vascular disease. Deficiency of folate and vitamin B-12 are associated with both hyper-homocysteinemia and dyslipidemia. The aim of the study is to evaluate the relationship of homocysteine and its associated dietary determinant levels (Folate and Vitamin B-12) with lipids and obesity parameters (WC, BMI, WHR) in North Indian population. Methods The participants were recruited under a major government funded project through household survey covering 15 villages of Haryana, India. Participants were both males and females, between age group 30–65 years, from a north Indian community. Initially 1634 individuals were recruited, of which 1374 were considered for analysis as they were not found to be on any kind of medication for high blood pressure, CAD, diabetes or any other disorder, and had no missing data. 5 mL of intravenous blood sample was collected after obtaining written informed consent from the participants. Homocysteine, folate and vitamin B12 levels were estimated through Immulite 1000 by chemi-luminescence technique. Triglyceride, total cholesterol and HDL-C were estimated by spectrophotometry technique using commercial kits. The values for LDL and VLDL were calculated using Friedwald’s equation. Height, weight, waist circumference (WC), hip circumference (HC) was measured over light clothing. Statistical analysis for data was performed using SPSS 16.0 version. Results All the lipid indices, except HDL, showed a trend of negative correlation with homocysteine after controlling for confounders, though not significant. No association was found between obesity (WC, BMI, WHR) and homocysteine in the present study. Vitamin B-12 deficiency was significantly associated with both hyper-homocysteinemia and low HDL. Folate was found to have significantly reduced risk for high TC & LDL. Conclusions The “hcy-lipid” hypothesis does not seem to be complementing in the present studied population. The population is vulnerable to severe under-nutrition due to the association of vitamin B-12 with HDL, leading to metabolic disturbance in both the pathways; lipid and one carbon metabolic pathway. Co-factors such as ethnicity, cultural practices, and lifestyle & dietary habits must be considered while making public health policies to control diseases. Electronic supplementary material The online version of this article (10.1186/s12944-018-0748-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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