Migration of Norway Rats Resulted in the Worldwide Distribution of Seoul Hantavirus Today
| Autor: | Ming-Hui Li, Jian-Fan Wen, Yong-Gang Qu, Yang Zou, Xian-Dan Lin, Wen-Ping Guo, Alexander Plyusnin, Wen Wang, Zong-Yu Hao, Dun-Jin Zhou, Yong-Zhen Zhang, Hai-Feng Tian, Jianguo Xu, Xue Dong |
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| Rok vydání: | 2012 |
| Předmět: |
Mitochondrial DNA
Disease reservoir Molecular Sequence Data 030231 tropical medicine Immunology Biology Microbiology Genetic analysis Viral Proteins 03 medical and health sciences 0302 clinical medicine Phylogenetics Virology Animals Humans Phylogeny Hantaan virus Disease Reservoirs Seoul virus 030304 developmental biology Genetics 0303 health sciences Phylogenetic tree Rats Phylogeography Genetic Diversity and Evolution Hemorrhagic Fever with Renal Syndrome Insect Science Viral evolution Animal Migration |
| Zdroj: | Journal of Virology. 86:972-981 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.00725-11 |
| Popis: | Despite the worldwide distribution, most of the known Seoul viruses (SEOV) are closely related to each other. In this study, the M and the S segment sequences of SEOV were recovered from 130 lung tissue samples (mostly of Norway rats) and from six patient serum samples by reverse transcription-PCR. Genetic analysis revealed that all sequences belong to SEOV and represent 136 novel strains. Phylogenetic analysis of all available M and S segment sequences of SEOV, including 136 novel Chinese strains, revealed four distinct groups. All non-Chinese SEOV strains and most of the Chinese variants fell into the phylogroup A, while the Chinese strains originating from mountainous areas clustered into three other distinct groups (B, C, and D). We estimated that phylogroup A viruses may have arisen only within the last several centuries. All non-Chinese variants appeared to be directly originated from China. Thus, phylogroup A viruses distributed worldwide may share a recent ancestor, whereas SEOV seems to be as diversified genetically as other hantaviruses. In addition, all available mitochondrial DNA (mtDNA) sequences of Norway rats, including our 44 newly recovered mtDNA sequences, were divided into two phylogenetic groups. The first group, which is associated with the group A SEOV variants, included most of rats from China and also all non-Chinese rats, while the second group consisted of a few rats originating only from mountain areas in China. We hypothesize that an ancestor of phylogroup A SEOV variants was first exported from China to Europe and then spread through the New World following the migration of Norway rats. |
| Databáze: | OpenAIRE |
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