Comparison of Noncancer Risk Assessment Approaches for Use in Deriving Drinking Water Criteria
| Autor: | Sharon deMonsabert, Mark C. Gibson, Jennifer Orme-Zavaleta |
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| Rok vydání: | 1997 |
| Předmět: |
Reference dose
Public drinking business.industry Water supply Regression analysis General Medicine Toxicology Risk Assessment United States Water Supply Adverse health effect Environmental protection Neoplasms Environmental health Humans Environmental science Water Pollutants United States Environmental Protection Agency Risk assessment business Categorical variable Strengths and weaknesses |
| Zdroj: | Regulatory Toxicology and Pharmacology. 26:243-256 |
| ISSN: | 0273-2300 |
| DOI: | 10.1006/rtph.1997.1150 |
| Popis: | The development and promulgation of drinking water regulations to protect exposed human populations from contaminants that may occur in public drinking water supplies has been a major regulatory concern and effort of the United States Environmental Protection Agency for decades. Risk assessment, as applied in the development of drinking water regulations, involves the quantification of the level below which adverse health effects are not expected to occur. Traditionally, the oral reference dose (RfD) has been the preferred approach for characterizing these noncancer health risks. The benchmark dose approach to derive RfDs has increasingly gained scientific and regulatory acceptance as a risk assessment methodology since its introduction in 1984. Similarly, the use of categorical regression techniques were introduced at about the same time. The objective of this paper is to present an evaluation of the strengths and weaknesses of each risk assessment method as related to the development of drinking water criteria for noncarcinogenic chemicals. The data base requirements, performance record, mathematical or statistical basis, and other parameters are described and compared. |
| Databáze: | OpenAIRE |
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