Design of an isolated pig heart preparation for positron emission tomography and magnetic resonance imaging
| Autor: | Karim Bendjelid, Marc Janier, Jean-François Obadia, Cendrine Casali, Emmanuelle Canet, Didier Revel, Xavier André-Fouët |
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| Rok vydání: | 1997 |
| Předmět: |
Materials science
Pig heart Swine Contrast Media In Vitro Techniques Fluorodeoxyglucose F18 Heterocyclic Compounds Brain positron emission tomography medicine Image Processing Computer-Assisted Organometallic Compounds Animals Radiology Nuclear Medicine and imaging Chelating Agents medicine.diagnostic_test business.industry Myocardium Myocardium metabolism Reproducibility of Results Magnetic resonance imaging Heart General Medicine Organ Size Magnetic Resonance Imaging Perfusion Positron emission tomography Research Design Tomography Radiopharmaceuticals Nuclear medicine business Tomography Emission-Computed |
| Zdroj: | Investigative radiology. 32(11) |
| ISSN: | 0020-9996 |
| Popis: | Validation of new positron emission tomography (PET) tracers or magnetic (MR) imaging contrast agents is based on isolated rodent heart preparations. The use of larger animals could provide a more direct validation using the devices used for humans.An isolated pig heart preparation has been developed and adapted to the technical constraints of whole body PET and MR imaging. This preparation could be used either in the Langendorff or working mode after selective cannulation of both coronary arteries.The authors showed that quantification of regional kinetics of PET tracers was possible using this preparation by measuring fluorine-18-labeled deoxyglycose (18FDG) kinetics in remote and ischemic territories. Experiments using MR imaging contrast agents, for myocardial perfusion, demonstrated the ability of this preparation to accurately validate these contrast agents over a wide range of flow rates.An isolated pig heart preparation could be developed to fulfill the constraints of PET and MR imaging, and proved useful for the study of the distribution of different tracers or contrast media developed for functional cardiac imaging in humans. |
| Databáze: | OpenAIRE |
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