Serum lipid profile and hepatic steatosis of adult beta-thalassaemia patients with chronic HCV infection
| Autor: | Dimitrios Siagris, Alexandra Lekkou, Konstantinos Thomopoulos, N. Zoumbos, C Papadimitriou, Myrto Christofidou, Arvaniti, Chryssoula Labropoulou-Karatza, Athanassios C. Tsamandas, Kouraklis-Symeonidis A |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Hepacivirus Hepatitis C virus medicine.disease_cause Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Triglycerides Hepatology medicine.diagnostic_test biology Triglyceride Cholesterol business.industry Cholesterol HDL beta-Thalassemia virus diseases Cholesterol LDL Hepatitis C Chronic biology.organism_classification medicine.disease Lipids digestive system diseases Fatty Liver Hemoglobinopathy chemistry Immunology Female Steatosis Lipid profile Viral hepatitis business |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 17:345-350 |
| ISSN: | 0954-691X |
| Popis: | OBJECTIVES The aim of this study was to evaluate the serum lipid profile and to assess the prevalence of hepatic steatosis in adult beta-thalassaemic patients with chronic hepatitis C virus (HCV) infection. METHODS Thirty-five adult HCV infected, multi-transfused, beta-thalassaemia patients (beta-HCV patients), 63 otherwise normal patients with chronic HCV infection (HCV patients) and 54 beta-thalassaemia patients without chronic viral hepatitis (beta patients) were studied. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, viral markers and liver histology were evaluated. RESULTS Serum total cholesterol, HDL-C and LDL-C were found at significantly lower levels in beta-HCV and beta patients than in HCV patients. Triglyceride levels were significantly lower in the HCV group compared with the beta group. Nine (25.7%) of the 35 beta-HCV patients had mild hepatic steatosis. Thirteen (23.6%) of 55 HCV patients presented mild and 4/55 (7.3%) moderate hepatic steatosis. None of the beta group presented steatosis. When we compared beta-HCV and HCV patients with steatosis, we found that beta-HCV patients had a lower degree of steatosis (11.1+/-7% vs 22.9+/-17.2%, P=0.021). Multivariate logistic regression analysis showed that the only independent predictor associated with hepatic steatosis in beta-HCV and HCV patients was genotype 3a (OR, 3.61; 95% CI, 1.22-10.71, P=0.021). CONCLUSIONS Adult beta-thalassaemia patients, compared to other patients with chronic HCV infection, present lower cholesterol levels (total cholesterol, HDL, LDL) and similar frequency but a lower degree of hepatic steatosis. This difference in the degree of steatosis is most likely due to the higher prevalence of genotype 3a in the non-beta-thalassaemia group. |
| Databáze: | OpenAIRE |
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