Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin
| Autor: | Nesbitt D. Brown, Dennis L. Butler, Peter K. Chiang |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Microcystins
Bacterial Toxins Guinea Pigs Molecular Sequence Data Pharmaceutical Science Beta-Cyclodextrins Dosage form Inclusion compound 2-Hydroxypropyl-beta-cyclodextrin chemistry.chemical_compound Drug Stability Ileum medicine Animals Thymopentin Amino Acid Sequence Pharmacology chemistry.chemical_classification Cyclodextrins Chromatography Cyclodextrin Cyanobacteria Toxins beta-Cyclodextrins Biological activity Muscle Smooth chemistry Marine Toxins Marine toxin medicine.drug Muscle Contraction Tropanes |
| Zdroj: | The Journal of pharmacy and pharmacology. 45(7) |
| ISSN: | 0022-3573 |
| Popis: | Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-β-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 × 10−6 m) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration. |
| Databáze: | OpenAIRE |
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