Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats
| Autor: | Patrick Mortas, Charles B. Nemeroff, Michael J. Owens, Steven C. Stout, Jean Luc Moreau |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Corticotropin-Releasing Hormone Central nervous system Gene Expression Adrenocorticotropic hormone Binding Competitive Receptors Corticotropin-Releasing Hormone Corticotropin-releasing hormone chemistry.chemical_compound Adrenocorticotropic Hormone Stress Physiological Corticosterone Internal medicine medicine Animals RNA Messenger Rats Wistar Pharmacology Depressive Disorder Behavior Animal business.industry Septal nuclei Anhedonia Rats Ventral tegmental area Stria terminalis medicine.anatomical_structure Endocrinology chemistry Septal Nuclei medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Pharmacology. 401:39-46 |
| ISSN: | 0014-2999 |
| Popis: | Chronic mild stress in rats is an antidepressant-responsive model for anhedonic symptoms of major depression. Many patients with depression exhibit alterations in hypothalamic-pituitary-adrenal axis activity, and corticotropin-releasing factor (CRF) neuronal function. This study investigated the potential involvement of CRF and CRF receptors in the development of chronic mild stress-induced anhedonia in rats. Rats were subjected to 19 days of chronic mild stress, during which time anhedonia was periodically assessed by determining the threshold for self-stimulation of the ventral tegmental area. Anhedonic rats exhibited a 50% increase in CRF concentrations in the bed nucleus of the stria terminalis compared to control rats. There were no significant changes in hypothalamic-pituitary-adrenal axis activity, CRF or CRF(1) receptor mRNA expression, or CRF receptor binding in the brain regions analyzed. Though preliminary, these results are consistent with the hypothesis that chronic stress-induced modulation of CRF function in specific brain structures such as the bed nucleus of the stria terminalis may contribute to the pathophysiology of depression. |
| Databáze: | OpenAIRE |
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