Scar imaging in the dyssynchronous left ventricle: Accuracy of myocardial metabolism by positron emission tomography and function by echocardiographic strain
| Autor: | Camilla Kjellstad Larsen, Elena Galli, Jürgen Duchenne, John M. Aalen, Caroline Stokke, Jan Gunnar Fjeld, Ganna Degtiarova, Piet Claus, Olivier Gheysens, Jorg Saberniak, Per Anton Sirnes, Erik Lyseggen, Jan Bogaert, Erik Kongsgaard, Martin Penicka, Jens-Uwe Voigt, Erwan Donal, Einar Hopp, Otto A. Smiseth |
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| Přispěvatelé: | Oslo University Hospital [Oslo], University of Oslo (UiO), CHU Pontchaillou [Rennes], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Akershus University Hospital [Lørenskog], University Hospitals Leuven [Leuven], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fonds Wetenschappelijk Onderzoek, FWO: 12ZZN22N, FKM1832917N, KU Leuven: OT12/084, Helse Sør-Øst RHF, sorost, Nasjonalforeningen for Folkehelsen |
| Rok vydání: | 2023 |
| Předmět: |
Glucose metabolism
Positron emission tomography Late gadolinium enhancement cardiac magnetic resonance Heart Ventricles Contrast Media Gadolinium Heart failure Myocardial scar Strain Cardiac Resynchronization Therapy Cicatrix Dyssynchrony Speckle tracking echocardiography [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Fluorodeoxyglucose F18 Echocardiography Positron-Emission Tomography Humans Prospective Studies Cardiology and Cardiovascular Medicine |
| Zdroj: | International Journal of Cardiology International Journal of Cardiology, 2023, 372, pp.122-129. ⟨10.1016/j.ijcard.2022.11.042⟩ |
| ISSN: | 0167-5273 1874-1754 |
| DOI: | 10.1016/j.ijcard.2022.11.042 |
| Popis: | PURPOSE: Response to cardiac resynchronization therapy (CRT) is reduced in patients with high left ventricular (LV) scar burden, in particular when scar is located in the LV lateral wall or septum. Late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) can identity scar, but is not feasible in all patients. This study investigates if myocardial metabolism by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and contractile function by echocardiographic strain are alternatives to LGE-CMR. METHODS: In a prospective multicenter study, 132 CRT candidates (91% with left bundle branch block) were studied by speckle tracking strain echocardiography, and 53 of these by FDG-PET. Regional myocardial FDG metabolism and peak systolic strain were compared to LGE-CMR as reference method. RESULTS: Reduced FDG metabolism (10% could rule out transmural scar with high sensitivity (80%) and high negative predictive value (96%). Neither FDG-PET nor strain identified septal scars (for both, AUC |
| Databáze: | OpenAIRE |
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