Supplementation Effect of a Combination of Olive (Olea europea L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension and Metabolic Syndrome
| Autor: | Philippe Lempereur, Joël Pincemail, Olivia Jansen, Michel P. Hermans, Nathalie Maes, Jean-Paul Salembier, Adelin Albert |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - (SLuc) Service d'endocrinologie et de nutrition |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Olea europea L Waist hypertension Physiology Fruit extracts Clinical Biochemistry Diastole 030204 cardiovascular system & hematology Biochemistry Article metabolic syndrome 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Olive leaf Oleuropein Internal medicine medicine Molecular Biology biology business.industry lcsh:RM1-950 Cell Biology biology.organism_classification medicine.disease lcsh:Therapeutics. Pharmacology 030104 developmental biology Endocrinology chemistry Olea oleuropein Hydroxytyrosol olive extracts Metabolic syndrome business hydroxytyrosol |
| Zdroj: | Antioxidants Volume 9 Issue 9 Antioxidants, Vol. 9, no. 9, p. 872 [1-15] (2020) Antioxidants, Vol 9, Iss 872, p 872 (2020) |
| ISSN: | 2076-3921 |
| Popis: | Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol®, Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol®, two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (p < 0.0001) in SBP/DBP (13 ± 10/7.1 ± 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol® supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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