The effect of carnosine on methylglyoxal-induced oxidative stress in rats
| Autor: | Müjdat Uysal, Merva Soluk-Tekkesin, A. Fatih Aydın, Semra Doğru-Abbasoğlu, Necla Koçak-Toker, Zülbiye Yılmaz, Esra Betül Kalaz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Glycation End Products
Advanced Male 0301 basic medicine medicine.medical_specialty Antioxidant Physiology medicine.medical_treatment Carnosine medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Protein Carbonylation Rats Sprague-Dawley Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound Glycation Physiology (medical) Internal medicine medicine TBARS Animals Methylglyoxal General Medicine Pyruvaldehyde Rats Oxidative Stress 030104 developmental biology Endocrinology Advanced Oxidation Protein Products Liver chemistry Biochemistry Advanced oxidation protein products Lipid Peroxidation Reactive Oxygen Species Injections Intraperitoneal Oxidative stress |
| Zdroj: | Archives of Physiology and Biochemistry. 123:192-198 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | Methylglyoxal (MG) is generated from glycolytic metabolites, lipid peroxidation, glucose autooxidation and protein glycation. It is a prooxidant inducing oxidative stress and formation of advanced glycation end products (AGE). Effect of carnosine (CAR) as an antioxidant on toxicity due to MG has generated interest. In this study, rats were given incrementally increased doses (100–300 mg/kg) of MG in drinking water for ten weeks. CAR (250 mg/kg i.p.) was administered with MG. Plasma thiobarbituric reactive substances (TBARS), protein carbonyl (PC), advanced oxidation protein products (AOPP) and AGE levels were elevated by MG, and CAR decreased PC, AOPP and AGE levels. MG increased liver reactive oxygen species (ROS), TBARS, PC and AOPP levels, which were decreased by CAR. Thus, in vivo role of CAR on chronic MG administration was observed to suppress the generated hepatic and plasma oxidative stress. |
| Databáze: | OpenAIRE |
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