Primary Histiocytic Sarcoma of the Central Nervous System

Autor:	Hoonsub So, Jihye Hwang, Cheolwon Suh, Chong Hyun Suh, Shin Kwang Khang, Sun A. Kim, Dok Hyun Yoon
Rok vydání:	2014
Předmět:	Cancer Research medicine.medical_specialty Pathology CD68 business.industry Central nervous system Cytarabine Case Report Histiocytic sarcoma medicine.disease Methotrexate medicine.anatomical_structure Oncology medicine Demyelinating disease Histopathology Nuclear atypia Sarcoma business Histiocyte
Zdroj:	Cancer Research and Treatment : Official Journal of Korean Cancer Association
ISSN:	2005-9256 1598-2998
DOI:	10.4143/crt.2013.163
Popis:	Histiocytic sarcoma is a type of lymphoma that rarely involves the central nervous system (CNS). Its rarity can easily lead to a misdiagnosis. We describe a patient with primary CNS histocytic sarcoma involving the cerebral hemisphere and spinal cord, who had been initially misdiagnosed as demyelinating disease. Two biopsies were necessary before a correct diagnosis was made. A histologic examination showed bizarre shaped histiocytes with larger nuclei and nuclear atypia. The cells were positive for CD68, CD163, and S-100 protein. As a resection was not feasible due to multifocality, he was treated with highdose methotrexate, but showed no response. As a result, he was switched to high dose cytarabine; but again, showed no response. The patient died 2 months from the start of chemotherapy and 8 months from the onset of symptoms. Since few patients with this condition have been described and histopathology is difficult to diagnose, suspicion of the disease is essential.
Databáze:	OpenAIRE
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