Nickel-Catalyzed Alkylation of Amide Derivatives
| Autor: | Nicholas A. Weires, Jacob E. Dander, Bryan J. Simmons, Neil K. Garg |
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| Rok vydání: | 2016 |
| Předmět: |
Ketone
chemistry.chemical_element Alkylation 010402 general chemistry 01 natural sciences Article Catalysis Metal Inorganic Chemistry chemistry.chemical_compound nickel Amide cross-coupling Organic chemistry alkylation chemistry.chemical_classification catalysis 010405 organic chemistry Organic Chemistry General Chemistry Chemical Engineering 0104 chemical sciences amides Nickel chemistry visual_art Reagent Yield (chemistry) visual_art.visual_art_medium |
| Zdroj: | ACS catalysis, vol 6, iss 5 |
| Popis: | We report the catalytic alkylation of amide derivatives, which relies on the use of nonprecious metal catalysis. Amide derivatives are treated with organozinc reagents, utilizing nickel catalysis, to yield ketone products. The methodology is performed at ambient temperature and is tolerant of variation in both coupling partners. A precursor to a nanomolar glucagon receptor modulator was synthesized using the methodology, underscoring the mild nature of this chemistry and its potential utility in pharmaceutical synthesis. These studies are expected to further promote the use of amides as synthetic building blocks. |
| Databáze: | OpenAIRE |
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