Author Correction: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
| Autor: | Jonathan D. Leslie, Maria Kotini, Roberto Mayor, Verena Rauschenberger, Alexandra Schambony, Marc Gentzel, Elias H. Barriga |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Science
General Physics and Astronomy Connexin Biology General Biochemistry Genetics and Molecular Biology Xenopus laevis In vivo Cell Movement Transcriptional regulation Animals Humans lcsh:Science Author Correction Multidisciplinary Gap junction protein Cadherin Nuclear Proteins General Chemistry DNA Polymerase II Cadherins Cell biology Gene Expression Regulation Neural Crest Connexin 43 lcsh:Q HeLa Cells Transcription Factors |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes. Here, we demonstrate that in addition to this canonical role, Connexins act as transcriptional regulators. We show that Connexin 43 (Cx43) controls neural crest cell migration in vivo by directly regulating N-cadherin transcription. This activity requires interaction between Cx43 carboxy tail and the basic transcription factor-3, which drives the translocation of Cx43 tail to the nucleus. Once in the nucleus they form a complex with PolII which directly binds to the N-cadherin promoter. We found that this mechanism is conserved between amphibian and mammalian cells. Given the strong evolutionary conservation of connexins across vertebrates, this may reflect a common mechanism of gene regulation by a protein whose function was previously ascribed only to gap junctional communication. |
| Databáze: | OpenAIRE |
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