Volumetric distribution of perivascular space in relation to mild cognitive impairment
| Autor: | Giuseppe Barisano, Wendy J. Mack, Ryan P. Cabeen, Haoyu Lan, Alzheimer’s Disease Neuroimaging Initiative, Malcolm S Crawford, Jeiran Choupan, Helena C. Chui, Nasim Sheikh-Bahaei, John M. Ringman, Farshid Sepehrband, Kirsten M. Lynch, Arthur W. Toga |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Amyloid Aging medicine.medical_specialty Neuroimaging tau Proteins Article Temporal lobe 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Distribution (pharmacology) Cognitive Dysfunction Perivascular space Cognitive decline Cognitive impairment Sex Characteristics medicine.diagnostic_test business.industry General Neuroscience Neurofibrillary Tangles Magnetic resonance imaging Cognition Organ Size Magnetic Resonance Imaging White Matter 030104 developmental biology medicine.anatomical_structure Hypertension cardiovascular system Cardiology Female Neurology (clinical) Cognitively impaired Geriatrics and Gerontology business Glymphatic System 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiol Aging |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2020.12.010 |
| Popis: | Vascular contributions to early cognitive decline are increasingly recognized, prompting further investigation into the nature of related changes in perivascular spaces (PVS). Using magnetic resonance imaging, we show that, compared to a cognitively normal sample, individuals with early cognitive dysfunction have altered PVS presence and distribution, irrespective of Amyloid-β. Surprisingly, we noted lower PVS presence in the anterosuperior medial temporal lobe (1.29 times lower PVS volume fraction in cognitively impaired individuals compared with those unimpaired, p < 0.0001), which was associated with neurofibrillary tau tangle deposition in the right entorhinal cortex (beta (SE) = −0.98 (0.4); p = 0.014), one of the hallmarks of early Alzheimer’s disease pathology. We also observed higher PVS volume fraction in centrum semi-ovale of the white matter, but only in female participants (1.47 times higher PVS volume fraction in cognitively impaired individuals compared with those unimpaired, p = 0.0011). Furthermore, we observed PVS changes in participants with history of hypertension (higher PVS volume fraction in the white matter and lower PVS volume fraction in the anterosuperior medial temporal lobe). Our results suggest that anatomically specific alteration of the PVS is an early neuroimaging feature of cognitive impairment in aging adults, which is differentially manifested in female. |
| Databáze: | OpenAIRE |
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