Pre and postnatal exposure to Chikungunya virus does not affect child neurodevelopmental outcomes at two years of age

Autor: Nikita Cudjoe, Roberta Evans, Randall Waechter, Amy R. Krystosik, Rashida Isaac, Veronica Mapp-Alexander, Michelle Fernandes, George Mitchell, Erinique Ingraham, Calum N. L. Macpherson, Ashlee Watts, Barbara Landon, Patrick Gérardin, A. Desiree LaBeaud, Priyanka Suresh, Trevor Noël
Přispěvatelé: Bodescot, Myriam, St. George's University [Grenada], Windward Islands Research and Education Foundation [Saint-Georges, Grenade] (WINDREF), Stanford University, University of Southampton, University of Oxford, Ministry of Health [Saint-Georges, Grenade], Centre d'Investigation Clinique de La Réunion - INSERM (CIC 1410), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), This study was supported by a grant from the National Institutes of Health (NIH), Fogarty International Center, 1R21TW010536 to RW and ADL. https://www.fic.nih.gov/Pages/Default.aspx, University of Oxford [Oxford], Centre National de la Recherche Scientifique (CNRS)-IRD-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de La Réunion (UR)
Rok vydání: 2020
Předmět:
RNA viruses
Male
0301 basic medicine
Viral Diseases
Pediatrics
Maternal Health
Developmental Disabilities
Neurodevelopment
RC955-962
Social Sciences
Pathology and Laboratory Medicine
medicine.disease_cause
Serology
Families
Medical Conditions
Child Development
0302 clinical medicine
Pregnancy
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Arctic medicine. Tropical medicine
Medicine and Health Sciences
Morphogenesis
Psychology
Medicine
Chikungunya
Pregnancy Complications
Infectious
Children
Language
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Chikungunya Virus
Obstetrics and Gynecology
virus diseases
3. Good health
Infectious Diseases
Medical Microbiology
Viral Pathogens
Child
Preschool
Viruses
Grenada
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Gestation
Female
Pathogens
Public aspects of medicine
RA1-1270
Pediatric Infections
Infants
Research Article
Neglected Tropical Diseases
medicine.medical_specialty
Alphaviruses
030231 tropical medicine
Gross motor skill
Mothers
Microbiology
Togaviruses
03 medical and health sciences
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
Humans
Serologic Tests
Microbial Pathogens
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Biology and life sciences
business.industry
Public health
Organisms
Cognitive Psychology
Infant
Newborn
Public Health
Environmental and Occupational Health
Chikungunya Infection
Infant
Outbreak
Tropical Diseases
medicine.disease
Child development
Infectious Disease Transmission
Vertical
030104 developmental biology
Age Groups
People and Places
Women's Health
Cognitive Science
Chikungunya Fever
Population Groupings
business
Developmental Biology
Neuroscience
Zdroj: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008546 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2020, 14 (10), pp.e0008546. ⟨10.1371/journal.pntd.0008546⟩
PLoS Neglected Tropical Diseases, Public Library of Science, 2020, 14 (10), pp.e0008546. ⟨10.1371/journal.pntd.0008546⟩
ISSN: 1935-2735
1935-2727
Popis: Background The 2005–06 chikungunya virus (CHIKV) outbreak in La Réunion suggested that mothers could transmit CHIKV to their neonates while viremic during the intrapartum period, and more than half of the infected neonates showed impaired neurodevelopment at two years of age. However, data sparsity precluded an overview of the developmental impact of vertical infection within the whole prenatal period. Objective & methods The current study assessed two-year old children born to mothers who were infected during the 2014 CHIKV outbreak in Grenada to determine the neurodevelopmental impact of perinatal CHIKV infection throughout gestation. Mother and child infection status were confirmed by serologic testing (IgG and IgM) for CHIKV. Cognitive, fine motor, gross motor, language and behavioral outcomes were assessed at two years of age on the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA). Results No differences in neurodevelopmental outcomes were observed between two-year-old children born to mothers infected with CHIKV during gestation (n = 149) and those born to mothers not infected with CHIKV (n = 161). No differences were found in INTER-NDA scores between children infected with CHIKV (n = 47) and children not infected with CHIKV (n = 592). Likewise, there were no differences between children infected with CHIKV post-partum (n = 19) versus children not infected with CHIKV (n = 592). Conclusion Our findings suggest that children exposed and/or infected with CHIKV outside of the intrapartum period experience no significant neurodevelopmental delay at two years of age, as measured by the INTER-NDA, compared to their unexposed and/or uninfected peers. These results complement those of previous studies which showed a neurodevelopmental risk only for children infected during the intrapartum period, while the mother was highly viremic. These results might be reassuring for women of childbearing age and public health officials in CHIKV-endemic regions.
Author summary The Chikungunya virus (CHIKV) can negatively impact fetal neurodevelopment and consequent neurocognitive functioning in young children. Studies from La Réunion island demonstrated that, compared to their uninfected counterparts, children infected by CHIKV during the intrapartum period were at increased risk for deficiencies in the frontal lobes where the language and coordination centers are located, as well as slight deficits in other neurocognitive skills like sociability, movement and posture. The current study assessed two-year old children born to mothers infected during the 2014 CHIKV outbreak in Grenada to determine the neurodevelopmental impact of perinatal infection throughout gestation. No differences in neurodevelopmental outcomes were observed between two-year-old children born to mothers infected with CHIKV during gestation and those born to mothers not infected with CHIKV, nor between children infected with CHIKV and children not infected with CHIKV. Our results support previous findings that a small proportion of children born in CHIKV-endemic regions are at risk as only mothers viremic during the intrapartum period are at risk of infecting their neonates. Healthcare providers in CHIKV-endemic regions may wish to monitor for CHIKV symptoms when pregnant women are near term. The relatively high symptomatic rate seen with CHIKV infection (75%) makes such monitoring feasible.
Databáze: OpenAIRE
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