The value of Ret-Hb and sTfR in the diagnosis of iron depletion in healthy, young children
| Autor: | J.B. van Goudoever, P. P. Teunisse, Frank Brus, Magnus Domellöf, Rimke C. Vos, J. Vloemans, Cisca Hudig, Sascha Verbruggen, Margriet A. B. Veldhorst, T.G. de Leeuw, S. Bubbers, L Uijterschout |
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| Přispěvatelé: | Anesthesiology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Paediatrics, Pediatric surgery, ICaR - Circulation and metabolism |
| Rok vydání: | 2014 |
| Předmět: |
Vitamin
congenital hereditary and neonatal diseases and abnormalities endocrine system medicine.medical_specialty Reticulocytes endocrine system diseases Anemia Medicine (miscellaneous) Hemoglobins chemistry.chemical_compound Reticulocyte Reference Values Internal medicine Receptors Transferrin medicine Humans neoplasms Soluble transferrin receptor Nutrition and Dietetics Anemia Iron-Deficiency biology business.industry Infant Iron Deficiencies Iron deficiency medicine.disease Cross-Sectional Studies Early Diagnosis medicine.anatomical_structure Endocrinology Biochemistry chemistry Health Child Preschool Ferritins biology.protein Hemoglobin business Body mass index Biomarkers Iron depletion |
| Zdroj: | European Journal of Clinical Nutrition, 68(8), 882-886. Nature Publishing Group Uijterschout, L, Domellof, M, Vloemans, J, de Vos, R, Hudig, C, Bubbers, S, Verbruggen, S, Veldhorst, M, de Leeuw, T, Teunisse, P P, van Goudoever, J B & Brus, F 2014, ' The value of Ret-Hb and sTfR in the diagnosis of iron depletion in healthy, young children ', European Journal of Clinical Nutrition, vol. 68, no. 8, pp. 882-886 . https://doi.org/10.1038/ejcn.2014.70 European journal of clinical nutrition, 68(8), 882-886. Nature Publishing Group |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/ejcn.2014.70 |
| Popis: | OBJECTIVES: Reticulocyte hemoglobin (Ret-Hb) content and soluble transferrin receptor (sTfR) are described as promising biomarkers in the analysis of iron status. However, the value of Ret-Hb and sTfR in the early detection of iron depletion, as frequently observed in children in high-income countries, is unclear. We hypothesized that young children to iron depletion, using the WHO cutoff of ferritin < 12 mu g/l, would have lower Ret-Hb and higher sTfR concentrations compared to children with a ferritin >= level 12 mu g/l. SUBJECTS/METHODS: In this cross-sectional study, we analyzed mean concentrations of Ret-Hb and sTfR in 351 healthy children aged 0.5-3 years in a high-income country. The Student's t-test was used to compare Ret-Hb and sTfR concentrations between groups. RESULTS: We showed that concentrations of Ret-Hb and sTfR are similar in children with and without iron depletion. A decrease in Ret-Hb concentration was present only when ferritin concentrations were < 8 mu g/l. sTfR concentrations were similar in children with ferritin concentrations < 6 mu g/l and >= 12 mu g/l. CONCLUSIONS: Our results showed that the discriminative value of Ret-Hb and sTfR for the detection of iron depletion is limited. Our findings suggest that ferritin is the most useful biomarker in the screening of iron depletion in healthy children in high-income countries. However, ideally, reference ranges of iron status biomarkers should be based on studies showing that children with concentrations outside reference ranges have poor neurodevelopmental outcomes. |
| Databáze: | OpenAIRE |
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