Metabolic pathway compartmentalization: an underappreciated opportunity?
| Autor: | Annalisa Zecchin, Peter Carmeliet, Peter C. Stapor, Jermaine Goveia |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Biomedical Engineering
Bioengineering Cell migration Mitochondrion Compartmentalization (psychology) Biology Subcellular localization Mitochondria Cell biology Metabolic pathway Adenosine Triphosphate Cell Movement Animals Humans Glycolysis Metabolic Networks and Pathways Intracellular Function (biology) Cellular compartment Biotechnology |
| Zdroj: | Current Opinion in Biotechnology. 34:73-81 |
| ISSN: | 0958-1669 |
| Popis: | For eukaryotic cells to function properly, they divide their intracellular space in subcellular compartments, each harboring specific metabolic activities. In recent years, it has become increasingly clear that compartmentalization of metabolic pathways is a prerequisite for certain cellular functions. This has for instance been documented for cellular migration, which relies on subcellular localization of glycolysis or mitochondrial respiration in a cell type-dependent manner. Although exciting, this field is still in its infancy, partly due to the limited availability of methods to study the directionality of metabolic pathways and to visualize metabolic processes in distinct cellular compartments. Nonetheless, advances in this field may offer opportunities for innovative strategies to target deregulated compartmentalized metabolism in disease. |
| Databáze: | OpenAIRE |
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