Hip Joint Distension in Osteoarthrosis:A Triple-blind Controlled Study Comparing the Effect of Intra-articular lndoprofen with Placebo
| Autor: | Birger Lund, C. Egsmose, R. B. Andersen |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Immunology Pain Osteoarthritis Distension Placebo Pain alleviation Injections Intra-Articular Placebos Intra articular Rheumatology Joint capsule medicine Humans Immunology and Allergy In patient Aged Clinical Trials as Topic Phenylpropionates business.industry Indoprofen General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure Anesthesia Female Hip Joint business medicine.drug |
| Zdroj: | Scandinavian Journal of Rheumatology. 13:238-242 |
| ISSN: | 1502-7732 0300-9742 |
| DOI: | 10.3109/03009748409100392 |
| Popis: | In a triple-blind controlled study, significant pain alleviation (p less than 0.01) was registered in patients with osteoarthrosis (OA) of the hip in the first 24 h after hip joint distension. There was no significant difference between treatment with indoprofen (a new non-steroidal anti-inflammatory drug for intra-articular use) and placebo. Pain relief lasted for at least 12 weeks in approximately half of the patients, in whom a significant increase in joint mobility was registered. Intra-articular indoprofen was not superior to placebo as regards pain relief or increased joint mobility. These findings indicate that the effect of a single hip joint distension in OA is due to a mechanical distension of the joint capsule, perhaps involving disruption of local agglutinations, and not due to suppression of inflammation. |
| Databáze: | OpenAIRE |
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