Current Strategies for Microbubble-Based Thrombus Targeting: Activation-Specific Epitopes and Small Molecular Ligands
| Autor: | Yuexin Chen, Yuehong Zheng, Huaigu Huang, Zhaojian Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Histology
Mini Review Biomedical Engineering small molecular ligand Bioengineering 02 engineering and technology 030204 cardiovascular system & hematology Epitope Fibrin microbubbles activation-specific probe 03 medical and health sciences 0302 clinical medicine medicine Platelet activation Free drug Thrombus thrombosis biology Chemistry Bioengineering and Biotechnology 021001 nanoscience & nanotechnology medicine.disease Coagulation supramolecular carriers biology.protein Cancer research Microbubbles 0210 nano-technology TP248.13-248.65 Biotechnology |
| Zdroj: | Frontiers in Bioengineering and Biotechnology Frontiers in Bioengineering and Biotechnology, Vol 9 (2021) |
| ISSN: | 2296-4185 |
| Popis: | Microbubbles with enhanced ultrasound represent a potentially potent evolution to the administration of a free drug in the treatment of thrombotic diseases. Conformational and expressional changes of several thrombotic biological components during active coagulation provide epitopes that allow site-specific delivery of microbubble-based agents to the thrombus for theranostic purpose. Through the interaction with these epitopes, emerging high-affinity small molecular ligands are able to selectively target the thrombi with tremendous advantages over traditional antibody-based strategy. In this mini-review, we summarize recent novel strategies for microbubble-based targeting of thrombus through epitopes located at activated platelets and fibrin. We also discuss the challenges of current targeting modalities and supramolecular carrier systems for their translational use in thrombotic pathologies. |
| Databáze: | OpenAIRE |
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