Differences in stimulatory effects between rat pancreatic secretory trypsin inhibitor-61 and -56 on rat pancreas
| Autor: | Kenichi Kitani, Michio Ogawa, Akihiro Funakoshi, Rieko Nakamura, Atsuo Murata, Ken-ichi Uda, Kyoko Miyasaka |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Exocrine gland Time Factors Physiology Molecular Sequence Data genetic processes Biology digestive system Internal medicine medicine Animals Amino Acid Sequence Pancreas Pancreatic Secretory Trypsin Inhibitor Cholecystokinin digestive oral and skin physiology Rats Inbred Strains General Medicine biochemical phenomena metabolism and nutrition Trypsin Rats medicine.anatomical_structure Endocrinology Gastrointestinal hormone Trypsin Inhibitor Kazal Pancreatic Pancreatic juice Duodenum bacteria Female Trypsin Inhibitor Kunitz Soybean Trypsin Inhibitors medicine.drug |
| Zdroj: | The Japanese Journal of Physiology. 39:891-899 |
| ISSN: | 1881-1396 0021-521X |
| DOI: | 10.2170/jjphysiol.39.891 |
| Popis: | Two types of pancreatic secretory trypsin inhibitors (PSTIs) were recently purified from rat pancreatic juice. One consisted of 61 (PSTI-61) and the other of 56 (PSTI-56) amino acid residues. PSTI-61 has been reported to elicit cholecystokinin (CCK) release when injected into the duodenum. Since no information has been available about the action of PSTI-56 on CCK release, the two PSTIs were compared for their stimulatory effect on CCK release and pancreatic exocrine secretions in conscious rats after intraduodenal administration. Rats were prepared with bile and pancreatic fistulae and with two duodenal cannulae. Pancreatic juice was excluded from the duodenum for 48 h prior to the experiment because rat PSTIs were trypsin sensitive. PSTI-61 significantly stimulated pancreatic secretions and increased plasma CCK concentrations from 3.6 to 6.5 pM, whereas PSTI-56 had no effect on either CCK release or pancreatic secretions. It is suggested that the action as a regulator for CCK release and pancreatic secretions is possessed only by PSTI-61, but not by PSTI-56. |
| Databáze: | OpenAIRE |
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