Dendritic cells from skin and blood of macaques both promote SIV replication with T cells from different anatomical sites
| Autor: | Melissa Pope, Frank Isdell, Una O'Doherty, Ralf Ignatius |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
T-Lymphocytes
Population Gene Products gag chemical and pharmacologic phenomena Spleen Biology Virus Replication Giant Cells Virus Cell Line Pathogenesis Immune system medicine Animals Humans education Cells Cultured Immunodeficiency Skin education.field_of_study General Veterinary Follicular dendritic cells Granulocyte-Macrophage Colony-Stimulating Factor hemic and immune systems Dendritic Cells medicine.disease Macaca mulatta Virology Coculture Techniques Recombinant Proteins medicine.anatomical_structure Immunology Female Simian Immunodeficiency Virus Animal Science and Zoology Interleukin-4 Lymph Nodes Lymph |
| Zdroj: | Journal of Medical Primatology. 27:121-128 |
| ISSN: | 0047-2565 |
| Popis: | The SIV-macaque system offers the opportunity to study the pathogenesis and immune aspects of a primate retroviral infection in which immunodeficiency also develops, much like HIV infection in humans. Since it is known that human dendritic cells (DCs) are involved in HIV replication, mature cytokine-generated DCs obtained from precursors in the blood and skin-derived DCs were isolated from healthy rhesus macaques and compared with respect to their ability to support SIV infection. Here, it is shown for both skin- and blood-derived DCs that i) virus production depends on both DCs and T cells, ii) this occurs similarly with T cells from blood, skin, spleen, or lymph nodes, and iii) DCs can transmit virus equally to syngeneic and allogeneic T cells. No differences between DCs from skin or blood were observed. Therefore, the easily accessible blood-derived DCs of macaques provide an appropriate population to study the role of DCs in immunodeficiency virus infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text