Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double blind, placebo controlled study
| Autor: | L. H. van den Berg, P. L. Oey, Marinus Vermeulen, I. Mollee, J.H.J. Wokke, H. Kerkhoff, Frans G. I. Jennekens, H. Franssen |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Placebo-controlled study Mismatch negativity Placebo Double blind Central nervous system disease Double-Blind Method hemic and lymphatic diseases medicine Humans Motor Neuron Disease business.industry Muscles Immunoglobulins Intravenous Middle Aged medicine.disease Surgery Clinical trial Psychiatry and Mental health Intravenous Immunoglobulins Anesthesia Female Neurology (clinical) business Research Article Multifocal motor neuropathy |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 59:248-252 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.59.3.248 |
| Popis: | The effect of high dose intravenous immunoglobulin (IVIg) treatment was studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) in an open trial. The effect of IVIg treatment was confirmed for each patient in a single patient, double blind, placebo controlled trial. Four patients received two IVIg treatments and two placebo treatments, and two patients received one IVIg and one placebo treatment in a randomised order. Five out of six patients responded to IVIg but not to placebo. One patient responded to IVIg in the same manner as to placebo treatment. Thus IVIg treatment can lead to improvement of muscle strength in patients with MMN. |
| Databáze: | OpenAIRE |
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