Elimination of central chemosensitivity by coagulation of a bilateral area on the ventral medullary surface in awake cats
| Autor: | H. H. Loeschcke, Marianne E. Schlaefke, J. F. Kille |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Medullary cavity
Physiology Clinical Biochemistry pCO2 Hypercapnia Lesion Physiology (medical) medicine Animals Respiratory system Decerebrate State Brain Mapping Medulla Oblongata Pyramidal tracts CATS business.industry Respiration Hypoventilation Syndrome Anatomy Carbon Dioxide Chemoreceptor Cells medicine.anatomical_structure Periodic breathing Anesthesia Cats Breathing medicine.symptom business |
| Zdroj: | Pfl�gers Archiv European Journal of Physiology. 378:231-241 |
| ISSN: | 1432-2013 0031-6768 |
| DOI: | 10.1007/bf00592741 |
| Popis: | Breathing and respiratory response to CO2 were observed in 6 awake cats and 1 control before and after bilateral coagulation of the formerly described area S (Schläfke and Loeschcke, 1967) on the ventral medullary surface under hyperoxic conditions. Ventilation decreased, PCO2 rose and CO2 response was almost or completely abolished in 4 cats, and moderately reduced in 2 cats. Inhalation of CO2 had an inhibitory effect on ventilation in two cases. In some instances the respiratory frequency was increased by CO2. Periodic breathing as well as spontaneous hyperventilation elicited by 'arousal' indicate parallels to the Pickwickian or Ondine's curse syndrome. No respiratory changes were produced by a lesion on the pyramidal tract medial to the area S. It is concluded that central chemosensitivity can be eliminated within the superficial layer of the area S. The loss of CO2 response seems to be correlated with complete destruction of the superficial nerve cells located within the area S (Petrovický, 1968) and degeneration within the ventral part of the nucleus paragigantocellularis. |
| Databáze: | OpenAIRE |
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