No Association Between Cholinergic Muscarinic Receptor 2 (CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples
| Autor: | Michelle Luciano, Timothy C. Bates, Riccardo E. Marioni, Neil Pendleton, Penelope A. Lind, Andrew Pickles, Nicholas G. Martin, Linda Gibbons, William E R Ollier, Jackie F. Price, Margaret J. Wright, Antony Payton, Ian J. Deary, Patrick Rabbitt, Michael A. Horan, Sarah E. Harris, Yvonne S Davidson |
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| Rok vydání: | 2009 |
| Předmět: |
Genetic Markers
Male Candidate gene Intelligence Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Cohort Studies Cognition Genetic variation Genetics Humans SNP Genetics (clinical) Ecology Evolution Behavior and Systematics Aged Aged 80 and over Family Health Receptor Muscarinic M2 Australia Genetic Variation Middle Aged England Scotland Genetic marker Cohort Female Cohort study |
| Zdroj: | Behavior Genetics. 39:513-523 |
| ISSN: | 1573-3297 0001-8244 |
| DOI: | 10.1007/s10519-009-9274-z |
| Popis: | Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor (CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts-one Scottish aged over 50 years (N = 2,091) and the other English comprising non-demented elderly participants (N = 758)-and a family-based Australian adolescent sample (N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability. |
| Databáze: | OpenAIRE |
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